Hot sale Cycloastragenol powder bulk (CAS:78574-94-4)–PHCOKER
What is Cycloastragenol ?
Cycloastragenol is a molecule derived from Astragalus membranaceus herb. The Astragalus herb has been used in Chinese medicine for centuries. The Chinese claimed that Astragalus can prolong life and it has been used it to treat fatigue, allergies, colds, heart disease and diabetes.
Cycloastragenol is one of the active ingredients in Astragalus. Cycloastragenol has a similar chemical structure to that of the Astragaloside IV molecule, but it is smaller and significantly more bioavailable, enabling lower doses to be taken. It is already used as an immunostimulant because of its ability to increase T lymphocyte proliferation. However, it is its exceptional anti-aging properties that are of increasing interest to the scientific community.
Cycloastragenol stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA. Telomeres are made of thin filaments and are found at the tips of chromosomes. Maintaining their stability enables cells to avoid replicative senescence and indefinite proliferation beyond the ‘Hayflick limit’. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of aging.
Mechanisms of action Cycloastragenol
A large number of studies have shown that progressive shortening of telomeres is closely associated with numerous age-related diseases (heart disease, infections, etc) and is also predictive of premature death in elderly subjects. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of aging.
Telomerase is a nucleoprotein enzyme which catalyses the synthesis and growth of telomeric DNA and stimulates the repair of DNA damage.
Cycloastragenol activates and stimulates this enzyme, thus curtailing the shortening of telomeres and also increasing their numbers. In this way, it allows lengthening of the telomeres and as a result, extends the cell’s lifespan.
Due to its low molecular weight, Cycloastragenol passes easily through the intestinal wall. Optimal assimilation allows higher efficacy, even at a low dose. Daily supplementation either on its own, or in combination or alternating with, astragaloside IV, will thus help to hold back ageing and naturally extend life expectancy.